neljapäev, 6. juuni 2013

fs: Sünteetiline analoogarvuti elavates rakkudes

 An analog computer inside a living cell 
 Pilt: Extremetech.com
                                                         
Mai keskel ajakirjas Nature avaldatud töös (Synthetic Analog Computation in Living Cells) näitavad MIT’i (Massachusetts Institute of Technology) teadlased, kuidas sünteetilisi analoog-geeni-ahelaid on võimalik panna elavates rakkudes teostama keerulisi arvutusi, kasutades vaid kolme transkriptsiooni faktorit. Sellel tööl on mitmeid rakendusi biotehnoloogias, meditsiinis ja energeetikas ning see on pioneeriks analoog-sünteetilise bioloogia ja analoogsüsteemide bioloogia valdkonnas, mis on seni keskendunud digitaalsetele lahendustele.

Enamasti on sünteetiliste geeni-ahelate loomisel elus rakkudes keskendutud digitaalsetele lahendustele, nagu kemikaali olemasolu või puudumine, kuid digitaalse sisendi muundamine digitaalseks väljundiks läheb vastuollu raku loomuliku kalduvusega reageerida analoog-muutustele, nagu kemikaali kontsentratsiooni suurenemine või vähenemine. Sundides analoogi-kalduvusega rakke tegutsema digitaalselt, on tulemuseks liiga keerulised ahelad. Analoogarvutused aga rakendavad funktsioone, mis rakkudes juba eksisteerivad, mistõttu need on märkimisväärselt efektiivsemad. MITi teadlaste molekulaarsed ahelad võivad arvutada logaritme, liita, lahutada, korrutada, jagada ja võtta ruutjuuri vähem kui kolme geeni osaga, võrreldes digitaalsete lahendustega, mis nõuavad sadu osi ja mida on raske rakkudes teostada.

Lisaks võivad analoogahelatel olla ka teistsugused kasutusalad, kui digitaalahelatel. Näiteks on võimalik panna ahel maksimeerima proteiini (nt insuliini) tootmist, vältides sealjuures toksilise tasemeni jõudmist. Digitaalne lahendus võimaldaks ainult insuliini tootmise sisse või välja lülitada, analoogahel aga võimaldab leida tasakaalupunkti võimalike insuliini tootmise tasemete vahel.

Töö põhineb varasemal uurimusel (Log-Domain Circuit Models of Chemical Reactions ), mis näitas, et on olemas hämmastavad sarnasused log-domeenide võrrandite vahel keemias ja analoog-elektroonikas.

21 kommentaari :

aboshady ütles ...

شركة مكافحة حشرات ببريدة
شركة مكافحة حشرات بالقصيم
شركة مكافحة حشرات بعنيزة
شركة مكافحة حشرات بالرس
مكافحة النمل الابيض ببريدة
مكافحة النمل الابيض بالقصيم
مكافحة النمل الابيض بعنيزة
مكافحة النمل الابيض بالرس

Mike77 ütles ...

It is very interesting to read these comments, I want to advise you on an excellent service that helped us write our articles when we needed to do this very quickly https://payforessay.net/

Ingailly ütles ...

Hello! Thank you everyone for reading and writing all the detailed information right here, which will be really interesting for me as well as for many other readers here! https://papernow.org/write-my-assignment

Nick001 ütles ...

Hi guys. Thank you for sharing very interesting information. I will be glad if I help someone too. As well as helping you to have a good time reading! Guys we are always looking for honest and reliable service and nobody likes to spend their free time, which can be spent on traveling, friends and self-development. Isn't it? If i'm right, there solution of all yours problems! There is a very cool service that has been helping schoolboys and students with their homework for a very long time. They are professionals and know what they are doing, you can definitely rely on them! That's all here https://domyhomeworkfor.me/c-homework-help you are welcome! Thanks! Have a good day and be happy!

oliverwright ütles ...

Hi guys! I've been using expert-writers for a while, and my essays always been professionaly, quick and originaly written. Price is affordable for students. Can't thank enough buy essays cheap service for their hard work. I already recommended them to my friends, who have been struggling to write assignments for university.

Brucehank12 ütles ...

Useful information. I am very happy to read this article..thanks for giving us this useful information. Are you not able to fix the problem with the Canon Printer? Just follow the steps which are mention on the blog to Resolve canon pixma mp495 wifi setup issue. Thanks!

adam scott ütles ...

Great, thanks for the information. It was really in search of this type of knowledge. Helpful to me at least! epson printer won't print black ink

Canon Support ütles ...

Setting up a printer might seem easy but it's the most important task and should be done following proper instructions and guidelines. If done wrong, canon printer setup can cause issues later and your printer might start showing errors. Therefore, we advice all the printer buyers to follow a strict set of instructions while setting up a printer. It includes-
• Proper printer driver installation which is compatible with your printer as well as your system.
• Proper network connectivity between the devices
• Stable internet connection
If you want to set up your printer under expert guidance, feel free to take help from the printer experts who are ready to serve you around the clock.

fixaolissues ütles ...

Your post is written in a perfect way. I really like your knowledge and your thoughts. I feel happy reading your post. Thank you for sharing that wonderful information.
Xfinity is the world-wide most popular & more secure server for email services. It becomes Xfinity Error Code 554 when the Xfinity server does not accept your message and bounce back to the sender of the email. The main reason for this error is the spam filtration of the Xfinity server or the AI of your domain is not trusted by the server for security reasons. You can dial our toll-free number that especially mentioned for customer support regarding your issues. We always provide best support related to your problems.

Ragani Tiwari ütles ...

What a post? I appreacite your idea or your efforts in the post. Thank you for sharing.
Akshi Engineers has the resources to manufacture Gear Boxes Manufacturer in India at affordable and reasonable prices. To learn more contact us to discuss how we can fulfill your requirement of Gear Boxes as soon as doable. Our Company offering all the equipment relates to the rolling mill industry with 100% satisfaction or quality at best prices in India and other countries. For more information contact us or visit our website.

harryparker0123 ütles ...

Hi Everyone! I, Harry parker, an experienced technical engineer, am performing at a trustworthy Tech-Support firm. I’m proficient enough and have extreme talents to affect any major or minor QuickBooks-related errors. I’m having hands of experience in solving technical errors including QuickBooks Error Code H505. I’m well-certified and really much serious about my work. I first plan and delve into the actual topic and thereafter I start writing in order that you'll get proper guidelines. It’s my role and responsibility to instruct you during a better way and that i always work therein.

PNJ Sharptech ütles ...

PNJ Sharptech, one of India's quickest web design services provider. Our affordable Website designing services team is fully equipped with the top set of skills, tools, and sources. With appealing graphics and accessible, complete user-friendly navigation our website designers team guarantees that your site not only brings just traffic but also engages and helps you to convert them to clients.

Also Read: How to Rank YouTube Videos Fast?

Ascent Fund Servics ütles ...

With years of expertise in the area of Alternative Investment Fund Administrator, Ascent Funds Services offers a comprehensive range of fund administration services including NAV Calculations, FATCA and CRS reporting, US tax reporting, Middle office, Corporate Accounting and Audit, Formation of Trust, and FX Solution.

Assignment Help ütles ...

Assignment writing is a very challenging and time taking task when you are in colleges or universities. This is why numerous candidates are looking for the Assignment Help services. If you are also thinking to contact the best assignment help company, call us today.

marklee9161 ütles ...

It is necessary to perform the Garmin maps update if Garmin devices have to be updated. Garmin Nuvi gives you access to all of the information you need, including maps, traffic updates, and interesting sites. Let's pretend you're going on a hiking or sightseeing excursion. You may have problems if you do not update the Nuvi map as soon as it becomes available. If you don't keep up with the essential improvements, you can end yourself circling the wrong path or traveling in the wrong direction. Garmin's devices are updated on a regular basis.

Write My Essay For Me Cheap Uk ütles ...

Visit our website and hire professional writers, tell them to do my UK essay for me, and sit back and wait for your assignment.

majortotositepro ütles ...

Well I definitely liked reading it. This information offered by you is very constructive for proper planning 메이저사이트

racesiteinfo ütles ...

I needed several examples to write an article on this subject, and your article was of great help to me 경마

oncasinositeinfo ütles ...

Thanks for sharing this vast knowledge to us in this single article. I really appreciate your work. You are going well. Keep it up and keep sharing. 카지노사이트

totopickpro ütles ...

Keep up the good work , I read few blog posts on this internet site and I believe that your site is really interesting and contains lots of fantastic info . 토토사이트

GamesBuild ütles ...

ngobrol games Tanks play a very important role. He must both safeguard the heart and become a hero if damage from the adversary is to be absorbed. gamesorbit Since a team wins the war easy without a good tank. We will give you with the 5 greatest tank heroes in 2021.

Postita kommentaar